Our Credibility
22 Years of Funded Science
Column of Hope funds research contracts directly — 98% of donations go to research and sponsored research conferences.
Summer 2025 Research Update
Where Column of Hope's research stands, from the labs in Sydney: what we set out to solve twenty years ago, what the team has proved since, and the step in front of us now.
Peer-Reviewed
Published Studies
Cardiorespiratory modulation of cerebrospinal fluid flow in the presence of spinal subarachnoid space obstruction
Berliner, Bilston, Stoodley · Fluids and Barriers of the CNS · 2026
Chiari malformation does not obstruct CSF flow during coughs
Lloyd/Stoodley · medRxiv · 2025
How volume changes in epidural space drives respiratory cerebrospinal fluid flow
Lloyd/Bilston · Journal of Biomechanics · 2025
Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model
Pukale · Fluids and Barriers of the CNS · 2024
A novel method to quantify perivascular space enlargement near the syrinx in a rodent model of post-traumatic syringomyelia
Stoodley · Nature - Scientific Reports · 2023
Aquaporin-4 expression and modulation in a rat model of post-traumatic syringomyelia
Stoodley · Nature - Scientific Reports · 2023
Cerebellar Tonsillar Descent Mimicking Chiari Malformation
Stoodley · Journal of Clinical Medicine · 2023
Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ISMRM Imaging Neurofluids Study group” Workshop in Rome
Stoodley · Journal of Magnetic Resonance Imaging · 2023
Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord
Stoodley · Fluids and Barriers of the CNS · 2022
Osmotic Contribution of Synthesized Betaine by Choline Dehydrogenase Using In Vivo and In Vitro Models of Post-traumatic Syringomyelia
Pukale · Cellular and Molecular Bioengineering · 2022
Statistical shape models of posteriour cranial fossa & hindbrain volumes may provide a more robust clinical metric for Chiari malformation
Stoodley · Journal of Biomechanics · 2022
Detection of locomotion deficit in a post-traumatic syringomyelia rat model using automated gait analysis technique
Leipzig · PLOS ONE COLLECTION - Nanomaterials · 2021
Osmoregulatory Role of Betaine and Betaine/γ-Aminobutyric Acid Transporter 1 in Post-Traumatic Syringomyelia
Leipzig · ACS Publications Chemical Neuroscience · 2021
Tachycardia and hypertension enhance tracer efflux from the spinal cord
Stoodley · Fluids and Barriers of the CNS · 2021
Abnormalities in spinal cord ultrastructure in a rat model of post-traumatic syringomyelia
Stoodley · Fluids and Barriers of the CNS · 2020
Respiratory cerebrospinal fluid flow is driven by the thoracic and lumbar spinal pressures
Stoodley · The Journal of Physiology · 2020
Cerebellar tissue strain in Chiari malformation with headache
Stoodley · World Neurosurgery · 2019
Effect of extradural constriction on CSF flow in rat spinal cord
Stoodley · Fluids and Barriers of the CNS · 2019
The effects of variation in the arterial pulse waveform on perivascular flow
Stoodley · Journal of Biomechanics · 2019
A Systematic Review of Cognition in Chiari I Malformation
Stoodley · Neuropsychology Review · 2018
Fluid outflow in the rat spinal cord: the role of perivascular and paravascular pathways
Stoodley · Fluids and Barriers of the CNS · 2018
Characteristics of CSF velocity-time profile in post-traumatic syringomyelia
Stoodley · American Journal of Neuroradiology · 2017
Chiari Malformation may Increase Perivascular Cerebrospinal Fluid Flow into the Spinal Cord: A Subject-Specific Computational Modelling Study
Stoodley · Journal of Biomechanics · 2017
Sustained high-pressure in the spinal subarachnoid space while arterial expansion is low may be linked to syrinx development
Bilston · Computer Methods in Biomechanics and Biomedical Engineering · 2017
Syrinx to subarachnoid shunting for syringomyelia
Stoodley · World Neurosurgery · 2017
The ultrastructure of spinal cord perivascular spaces: Implications for the circulation of cerebrospinal fluid
Stoodley · Nature - Scientific Reports · 2017
Treatment of syringomyelia in patients with arachnoiditis at the cranio-cervical junction
Stoodley · World Neurosurgery · 2017
Cerebellar and hindbrain motion in Chiari Malformation with and without syringomyelia
Stoodley · Journal of Neurosurgery - Spine · 2016
Direct-trauma model of post-traumatic syringomyelia with a computer-controlled motorized spinal cord impactor
Stoodley · Journal of Neurosurgery · 2016
Inwardly rectifying potassium channel 4.1 expression in post-traumatic syringomyelia
Stoodley · Neuroscience Letters · 2016
Longitudinal measurements of syrinx size in a rat model of post-traumatic syringomyelia
Stoodley · Journal of Neurosurgery · 2016
The cervical spinal canal tapers differently in patients with Chiari I with and without syringomyelia
Houghton · American Journal of Neuroradiology · 2016
Effects of fluid structure interaction in a three dimensional model of the spinal subarachnoid space
Stoodley · Journal of Biomechanics · 2014
Numerical simulations of the pulsating flow of cerebrospinal fluid flow in the cervical spinal canal of a Chiari patient
Simula · Journal of Biomechanics · 2014
Aquaporin-4 expression in post-traumatic syringomyelia
Stoodley · Journal of Neurotrauma · 2013
Changes in temporal flow characteristics of CSF in Chiari malformation Type I with and without syringomyelia: implications for theory of syrinx development
Stoodley · Journal of Neurosurgery · 2013
Computational fluid dynamics modelling of cerebrospinal fluid pressure in Chiari malformation and syringomyelia
Stoodley · Journal of Biomechanics · 2013
Aquaporin-4 expression and blood–spinal cord barrier permeability in canalicular syringomyelia Laboratory investigation
Stoodley · Journal of Neurosurgery · 2012
Fluid Outflow in a Large-Animal Model of Post-traumatic Syringomyelia
Stoodley · Congress of Neurological Surgeons · 2012
Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines
Eaton · Pain Research and Treatment · 2012
The presence of arachnoiditis affects the characteristics of CSF flow in the spinal subarachnoid space: A modelling study
Stoodley · Journal of Biomechanics · 2012
Mechanisms of cerebellar tonsil herniation in patients with Chiari malformations as guide to clinical management
TCI · Acta Neurochirurgica · 2010
The influence of the relative timing of arterial and subarachnoid space pulse waves on spinal perivascular cerebrospinal fluid flow as a possible factor in syrinx
Stoodley · Journal of Neurosurgery · 2010
Use of progenitor cells in pain management
Eaton · Stem Cell and Regenerative Medicine · 2010
Clinical feasibility for cell therapy using human neuronal cell line to treat neuropathic behavioral hypersensitivity following spinal cord injury in rats
Eaton · Journal of Rehabilitation and Research · 2009
Role of Blood-spinal cord barrier in PTSM Role of the blood-spinal cord barrier in post-traumatic syringomyelia
Stoodley · Journal of Neurosurgery · 2009
Optimizing the transplant dose of a human neuronal cell line graft to treat SCI pain in the rat
Eaton · Neuroscience Letters · 2007
Subarachnoid Transplant of a Human Neuronal Cell Line Attenuates Chronic Allodynia and Hyperalgesia After Excitotoxic Spinal Cord Injury in the Rat
Eaton · The Journal of Pain · 2007